DNA damage in normally and prematurely aged mice

P-62: Damage to Sperm DNA and Protamine Deficiency Induced by Risperidone in NMRI Mice

Background: Antipsychotic medication use is a common cause of hyperprolactinemia that shown to have adverse effects on male fertility. Risperidone is a combined serotonin/dopamine receptor antagonist that can cause elevations in prolactine level. Its mechanism of cytotoxic effects on testicular germ cells is not fully understood. In the present study we sought to elucidate the impact of risperi...

P-235: Ceftriaxone Effects on Sperm Quality and DNA Damage in Adult Mice

Background: Ceftriaxone is a third-generation Cephaloporin antibiotic. It has broad spectrum activity against gram-positive and gram-negative bacteria. There are some reports about its adverse effects on sperm quality and quantity but there is a need for more investigations so we did it. Materials and Methods: 40 adult male mice were divided into 3 groups as followings: a control group, high do...

Radiation track and DNA damage

Microglia in the normally aged hippocampus

The hippocampus plays important roles in the regulation and combination of short and long term memory and spatial navigation with other brain centers. Aging is accompanied by a functional decline of the hippocampus and degenerative disease. Microglia are major immune cells in the central nervous system and response to degenerative changes in the aged brain. In this respect, functional and morph...

DNA fragmentation of oocytes in aged mice.

To investigate whether female fertility decreases with age due to poor oocyte quality, we examined the presence of DNA fragmentation in ovulated oocytes from young, mature and aged mice. Oocytes from three age groups of female mice (7-8, 20-24 and 40-48 weeks) were retrieved from the oviducts 15 h after human chorionic gonadotrophin (HCG) injection. Oocytes from each mouse were incubated in a C...